The expert guide to prejuvenation: how to combine effective skincare with adjustments

From miracle creams to multitasking serums, it’s tempting to think that all of our skincare woes can be solved with just one product. Unfortunately, it’s not that simple, and certainly not if left too late. What we can do, however, for those who want it, is to combine an effective skincare routine with a new wave of cutting-edge tweaks. But the key is to start now. Welcome to the era of prejuvenation.

“Prejuvenation is a preventative protocol that combines a good skincare regimen with non-surgical treatments to help promote collagen production and support the skin barrier,” explains Dr. Yannis Alexandrides, cosmetic surgeon and founder of the 111 Harley Street Cosmetic Clinic. “In generations past, most people waited to see their first wrinkles to look for ways to rejuvenate the skin. Today, with so much information and education at our fingertips through social media, combined with advancements skincare and aesthetics, young people (even in their 20s and into their early 30s) are looking for preventative ways to keep their skin in good condition.”

So what exactly can these treatments do? Plenty. From skin thinning, pigmentation and pore size to sagging skin, fat pad movement, bone resorption and the appearance of jowls, these procedures target the degenerative effects of aging on your skin. . “The benefits are the delay in the appearance of the signs of ageing, as well as the delay in the need for more invasive treatments,” says Dr Marco Nicoloso, who offers a range of procedures at Ouronyx in London. “You’ll also look completely refreshed and the best version of yourself without looking like you’ve had any treatments because the results are so natural.” It’s essentially a way to maintain a healthy complexion for longer because, as award-winning esthetician, Dr. Ahmed El Muntasar says, “Prevention is better than cure.”

Below, vogue brings together the best treatments available for prejuvenation, according to experts.


While you may be familiar with dermal fillers, you may not be as familiar with Ellanse. “Ellanse is a fast-acting collagen biostimulator that is injected dermal or sometimes subcutaneously into the skin, where collagen stimulation occurs,” says Dr. Muntasar. “Collagen is a vital compound for healthy skin and its injection into a blood vessel stimulates growth so that the body can be revitalized in no time.” Although the effects are immediate, Ellanse also works to gradually stimulate the body’s natural collagen production over time, giving you results that can last up to five years. It is a versatile treatment that can be used to restore lost facial volume, especially in areas such as the cheeks, jawline, temples and chin, as well as to visibly reduce fine lines and wrinkles. The best news? There is no downtime.

Secret RF

If you’re not quite ready for injectables, Dr. Nicoloso recommends Secret RF. “At Ouronyx, we have the latest technologies in radiofrequency and microneedling. Secret RF harnesses the power of both for a highly effective treatment to stimulate collagen production and skin renewal, and has an anti-aging effect to rejuvenate the skin. A unique system, Secret RF uses micro-needles to deliver fractional radiofrequency energy to different levels of the skin, coagulating blood and creating hemostasis. This then causes the blood to thicken, replicating the same action as collagen in the body. By adjusting the needles, you can tailor the treatment to your individual needs, whether it’s targeting fine lines and wrinkles or acne scars, photoaging and stretch marks. For optimal results, Dr. Nicoloso recommends up to three or four treatments over an 18 month period, although you should start seeing results after your second treatment.


Combining microneedling and radiofrequency, Potenza does a similar thing. “This triggers your body’s natural healing process,” says Dr. Alexandrides. “This regeneration process promotes the production of collagen and elastin, which rejuvenates and revitalizes the skin. Combining the two methods – microneedling and radio frequency – gives faster and better results rather than using one technology for all skin types. Plus, it gives you the ability to truly personalize the treatment based on individual skin concerns and skin type. “Overall, you’ll notice firmer, tighter, more youthful-looking skin and a smoother, more luminous complexion.” Although you will definitely start to see the effects after one to two treatments, for optimal results a plan of four to five sessions is generally recommended, four to six weeks apart. The only thing to keep in mind is downtime. Expect two to three days of redness. You also cannot do Botox or fillers two weeks before or after treatment, and you must stop using retinol and retin-A at least seven days before your treatment.

Thermage FLX

Thermage FLX is another treatment that uses radio frequency to promote collagen production and prevent sagging skin. According to Dr. Alexandrides, this is one of the most popular procedures at 111 Harley Street Cosmetics Clinic. Using the latest in advanced technology, Thermage FLX heats the skin, increasing levels of elasticity to smooth, lift and tighten areas around the upper and lower eyelids, lower face and stomach, as well as other areas from the body. It can also improve jawline definition and reduce wrinkles. You will see immediate lifting effects, but the results of Thermage FLX are usually gradual over six months and can last between one and three years, so only one session per year is recommended.


If radio frequency isn’t your thing, Profilho is a great alternative. “This treatment provides the skin with pure hyaluronic acid, but more than just hydration, it also acts as a biostimulator that improves the quality of the skin without changing the shape or volume of the face”, explains Dr. Nicoloso . Using two types of hyaluronic acid in high concentrations, drops are injected into the skin and left to dissolve for over 12 hours, where they then fill in fine lines and wrinkles and improve overall skin texture. For optimal results, Dr. Nicoloso suggests a course of two treatments, one month apart, with effects lasting up to six months. “The great thing with this treatment is that it has minimal downtime,” he adds.


PRP Therapy (otherwise known as Platelet Rich Plasma, or the “Vampire Facial”) is used to initiate the body’s regenerative processes creating a rejuvenating effect. The injectable treatment extracts and reinjects the proteins and platelets into the skin that give radiance for a luminous and radiant complexion. “PRP treatments help stimulate the production of collagen, elastin and new cells,” says Dr. Alexandrides. “It is effective in treating fine lines and wrinkles, improving skin tone and texture. We also recommend it as a complementary treatment if you are using Potenza to maximize your results.

skin boosters

Skin boosters do exactly what you expect them to: they improve the overall appearance of your complexion. “Skin boosters are a natural injectable treatment that leaves your skin hydrated, recovered and rejuvenated,” says Dr. Muntasar. “It’s basically injecting vitamins, minerals, amino acids and hyaluronic acid – the building blocks of healthy skin – into the epidermis.” Working to rehydrate dry, damaged and even dull skin, it can be applied to areas such as the face, neck, décolleté, chest and hands. Effects can take up to four weeks to appear and can last up to nine months.

Baby Botox

Unlike the frozen look of Botox of past generations, the effects of Botox today are much more subtle. “By weakening the muscles, Botox prevents them from moving and causing wrinkles,” says Dr. Alexandrides. “Most people wait to see wrinkles before seeking Botox treatment, but preventative treatment uses Botox to treat wrinkles before they appear. We can strategically inject a small amount of Botox to target fine lines before they deepen and turn into wrinkles. This is something Dr. Nicoloso is also keen to recommend. “Baby Botox is a very natural way of having Botox. With smaller doses of toxin, it still works to prevent deep wrinkles from appearing, but the face looks more natural. Typically, the effects of Botox can last up to three to four months, at which time it’s good to stock up.

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